US 7,612,200 B2 · Inhibitors of protein kinases

Abstract

The present invention is directed to a compound having the formula wherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.

Claims1

Dependent claims

A compound selected from the group consisting of

1-[5-tert-butyl-3-(1,1-dioxo-1λ6-[1,2,5]thiadiazepane-5-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea;
1-[5-tert-butyl-3-(3-oxo-piperazine-1-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea;
1-[5-tert-butyl-3-(1,1-dioxo-1λ6-thiomorpholine-4-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea;
and
1-[5-tert-butyl-3-(5-oxo-[1,4]diazepane-1-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea;
or pharmaceutically acceptable salt thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

11/295,433Filed 7 Dec 2005 · us provisional application

Priority

7 Dec 2004

Published

US 2009/0192307 A130 Jul 2009

Granted

3 Nov 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification42 codes

C07D 409/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 1/18
Drugs for disorders of the alimentary tract or the digestive system: for pancreatic disorders, e.g. pancreatic enzymes

Inhibitors of protein kinases

Life of this patent

Inhibitors of protein kinases

Life of this patent

Abstract

Claims1