Co-stimulatory polypeptides
AssigneeMaxygen, Inc.
InventorsJuha Punnonen, Alexandra L. L. Lazetic, Steven R. Leong, Jean Chia-Chun Chang
Life of this patent
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Abstract
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
Claims21
An isolated or recombinant polypeptide comprising a polypeptide sequence having at least 99% amino acid sequence identity to the polypeptide sequence of an extracellular domain of SEQ ID NO:86, wherein the polypeptide binds CTLA-4 or an extracellular domain of CTLA-4.
An isolated or recombinant polypeptide comprising (i) a first polypeptide comprising a polypeptide sequence having at least 99% amino acid sequence identity to the polypeptide sequence of an extracellular domain of SEQ ID NO:86, wherein the first polypeptide has a CTLA-4/CD28 binding affinity ratio equal to or greater than the CTLA-4/CD28 binding affinity ratio of the extracellular domain of human B7-1, and (ii) a second polypeptide comprising at least a portion of an immunoglobulin (Ig) polypeptide.
An isolated or recombinant polypeptide comprising a polypeptide sequence having at least 98% amino acid sequence identity to the polypeptide sequence of a mature domain of SEQ ID NO:86, wherein the polypeptide has a CTLA-4/CD28 binding affinity ratio equal to or greater than the CTLA-4/CD28 binding affinity ratio of the mature domain of human B7-1 or an ability to inhibit T cell proliferation.
An isolated or recombinant polypeptide comprising a polypeptide sequence having at least 98% amino acid sequence identity to the full-length polypeptide sequence of SEQ ID NO:86, wherein the polypeptide binds CTLA-4 or inhibits T cell proliferation.
Dependencies are inferred from the claim text.