Aqueous pharmaceutical compositions

An antibacterial aqueous pharmaceutical composition which comprises:

• 2.8 to 4 w/v % of methylcellulose, wherein a 2 w/v % aqueous solution of said methylcellulose has a viscosity of 12 mPa·s or below at 20° C.;
• 1.5 to 2.3 w/v % of citric acid;
• 2 to 4 w/v % of polyethylene glycol;
• and 0.1 to 0.5 w/v % of at least one kind of new quinolone antibacterial agent selected from the group consisting of ofloxacin, levofloxacin and moxifloxacin hydrochloride.

An aqueous pharmaceutical composition which comprises:

• 2.3 to 8 w/v % of methylcellulose, wherein a 2 w/v % aqueous solution of said methylcellulose has a viscosity of 12 mPa·s or below at 20° C.;
• 0.14 to 4 w/v % of at least one kind of acid selected from the group consisting of multivalent carboxylic acid, lactic acid and gluconic acid;
• and
• an effective amount of a pharmaceutical agent, wherein said pharmaceutical agent is at least one member selected from the group consisting of ciprofloxacin hydrochloride, norfloxacin, lomefloxacin hydrochloride, gatifloxacin, carteolol hydrochloride, betaxolol hydrochloride, timolol maleate, pilocarpine hydrochloride, isopropylunoproston, nipradirol, bromfenac sodium, pranoprofen, diclofenac sodium, ketotifen fumarate, acitazanolast, disodium cromoglicate, tranilast, bethametasone sodium phosphate, prednisolone acetate, fluorometolone, fluorescein sodium, gentamicin sulfate, prienoxine, cyclosporine A. acyclovir, tropicamide and phenylephrine hydrochloride.

An aqueous pharmaceutical composition which comprises:

• 2.3 to 8 w/v % of methylcellulose, wherein 2 w/v % aqueous solution of said methylcellulose has a viscosity of 12 mPa·s or below at 20° C.;
• 0.5 to 13 w/v % of polyethylene glycol;
• and
• an effective amount of a pharmaceutical agent, wherein said pharmaceutical agent is at least one member selected from the group consisting of ciprofloxacin hydrochloride, norfloxacin, lomefloxacin hydrochloride, gatifloxacin, carteolol hydrochloride, betaxolol hydrochloride, timolol maleate, pilocarpine hydrochloride, isopropylunoproston, nipradirol, bromfenac sodium, pranoprofen, diclofenac sodium, ketotifen fumarate, acitazanolast, disodium cromoglicate, tranilast, bethametasone sodium phosphate, prednisolone acetate, fluorometolone, fluorescein sodium, gentamicin sulfate, prienoxine, cyclosporine A, acyclovir, tropicamide and phenylephrine hydrochloride.

An aqueous pharmaceutical composition which comprises:

• 2.3 to 8 w/v % of methylcellulose, wherein a 2 w/v % aqueous solution of said methylcellulose has a viscosity of 12 mPa·s or below at 20° C.;
• 0.14 to 4 w/v % of at least one kind of acid selected from the group consisting of multivalent carboxylic acid, lactic acid and gluconic acid;
• 0.5 to 13 w/v % of polyethylene glycol;
• and
• an effective amount of a pharmaceutical agent, wherein said pharmaceutical agent is at least one member selected from the group consisting of ciprofloxacin hydrochloride, norfloxacin, lomefloxacin hydrochloride, gatifloxacin, carteolol hydrochloride, betaxolol hydrochloride, timolol maleate, pilocarpine hydrochloride, isopropylunoproston, nipradirol, bromfenac sodium, pranoprofen, diclofenac sodium, ketotifen fumarate, acitazanolast, disodium cromoglicate, tranilast, bethametasone sodium, phosphate, prednisolone acetate, fluorometolone, fluorescein sodium, gentamicin sulfate, prienoxine, cyclosporine A, acyclovir, tropicamide and phenylephrine hydrochloride.