US 7,612,107 B2 · Treatment and inhibition of disease conditions using flexible heteroarotinoids

Abstract

The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions which can benefit from treatment with flexible heteroarotinoids as described herein are, (1) cancers and other diseases that involve abnormal differentiation, (2) diabetes, (3) hemophilia, (4) liver disease, (5) diseases involving human aldehyde dehydrogenase 2, (6) polycystic kidney disease, (7) lysosomal storage diseases, (8) high cholesterol, (9) obesity, (10) high triglycerides, (11) glycoprotein metabolism diseases, and (12) diseases involving abnormal angiogenesis.

Claims4

Dependent claims

A method for treating or inhibiting polycystic kidney disease in a subject in need of treatment thereof or at risk therefor, comprising:

providing a quantity of a flexible heteroarotinoid having a urea or thiorurea linker wherein the flexible heteroarotinoid is selected from the group consisting of SHetA2, SHetA3, and SHetA4;
and
administering to the subject the flexible heteroarotinoid having a urea or thiourea linker.

Dependencies are inferred from the claim text.

Facts

Application

11/404,701Filed 14 Apr 2006 · us provisional application

Priority

15 Apr 2005

Published

US 2006/0252817 A19 Nov 2006

Granted

3 Nov 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 31/382
Having sulfur as a ring hetero atom: having six-membered rings, e.g. thioxanthenes
A61K 31/38
Heterocyclic compounds: having sulfur as a ring hetero atom
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/00
Drugs for disorders of the metabolism

Treatment and inhibition of disease conditions using flexible heteroarotinoids

Life of this patent

Treatment and inhibition of disease conditions using flexible heteroarotinoids

Life of this patent

Abstract

Claims4