Bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, processes for their preparation, pharmaceutical compositions and methods for their use

A compound of formula I:

• wherein
• R1 is selected from the group consisting of (C1-C6)alkyl, (C0-C6)alkylene (C3-C6) cycloalkyl, (C0-C6)alkylene-O—(C1-C6)alkyl, (C0-C6)alkylene-O—(C3-C6) cycloalkyl, (C0-C6)alkylene-(C6-C14)aryl and (C0-C6) alkylene-(C5-C15) heteroaryl, wherein the alkyl, alkylene, aryl, heteroaryl and cycloalkyl can be unsubstituted or mono, di- or trisubstituted by F, Cl, Br, OCF3, CN, CO—(C1-C6) alkyl, COO(C1-C6)alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H), or S(O)m (C1-C6)alkyl;
• R2, R3, R4 and R5 are independently selected from the group consisting of H, halogen, (C1-C6)alkyl, (C0-C4)alkylene-O—(C0-C4)alkylene-H, CN, COO(C1-C6)alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H) and S(O)m(C1-C6)alkyl, wherein the alkyl and alkylene are unsubstituted or mono, di- or trisubstituted by F;
• A is (C6-C14)aryl;
• n is 1, 2, or 3;
• m and z are 0, 1, or 2;
• and
• R6, R7 and R8 are independently selected from the group consisting of H, (C1-C6)alkyl, CN, CO—(C1-C6)alkyl, COO—(C1-C6)alkyl, CON((C0-C6)alkylene-H((C0-C6) alkylene-H), S(O)m(C1-C6)alkyl, N((C0-C6)alkylene-H)((C0-C6)alkylene-H), N((C0-C6)alkylene-H)—CO—(C1-C6)alkyl, N((C0-C6)alkylene-H)—CO—(C1-C6) alkyl, halogen, (C0-C6)alkylene-O—(C0-C6)alkylene-H, (C0-C6)alkylene-O—(C6-C14) aryl, SCF3, S(O)2CF3 and NO2, wherein the alkyl, aryl and alkylene are unsubstituted or mono, di- or trisubstituted by F and the aryl can be unsubstituted or monosubstituted by CF3;
• or a stereoisomer, enantiomer, tautomer, or physiologically acceptable salt thereof.