Tri-substituted heteroaryls and methods of making and using the same

A compound of the following formula:

• or an N-oxide or a pharmaceutically acceptable salt thereof,
• wherein
• R1 is aryl, heteroaryl, aralkyl, or heteroaralkyl;
• each Ra is independently alkyl, alkenyl, alkynyl, alkoxy, acyl, halo, hydroxy, amino, nitro, oxo, thioxo, cyano, guanadino, amidino, carboxy, sulfo, mercapto, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, aminocarbonyl, alkylcarbonylamino, alkylsulfonylamino, alkoxycarbonyl, alkylcarbonyloxy, urea, thiourea, sulfamoyl, sulfamide, carbamoyl, cycloalkyl, cycloalkyloxy, cycloalkylsulfanyl, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylsulfanyl, aryl, aryloxy, arylsulfanyl, aroyl, heteroaryl, heteroaryloxy, heteroarylsulfanyl, or heteroaroyl;
• X is piperidinyl, piperazinyl, pyrrolidinyl, tetrahydrofuran, cyclohexyl, cyclopentyl, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.1]octane, 2-oxa-bicyclo[2.2.2]octane, 2-aza-bicyclo[2.2.2]octane, 3-aza-bicyclo[3.2.1]octane, or 1-aza-bicyclo[2.2.2]octane;
• Y is a bond, —C(O)—, —C(O)—O—, —O—C(O)—, —S(O)p—O—, —O—S(O)p—, —C(O)—N(Rb)—, —N(Rb)—C(O)—, —O—C(O)—N(Rb)—, —N(Rb)—C(O)—O—, —O—S(O)p—N(Rb)—, —N(Rb)—S(O)p—O—, —N(Rb)—C(O)—N(Rc)—, —N(Rb)—S(O)p—N(Rc)—, —C(O)—N(Rb)—S(O)p—, —S(O)p—N(Rb)—C(O)—, —C(O)—N(Rb)—S(O)p—N(Rc)—, —C(O)—O—S(O)p—N(Rb)—, —N(Rb)—S(O)p—N(Rc)—C(O)—, —N(Rb)—S(O)p—O—C(O)—, —S(O)p—N(Rb)—, —N(Rb)—S(O)p—, —N(Rb)—, —S(O)p—, —O—, —S—, or —(C(Rb)(Rc))q—, wherein each of Rb and Rc is independently hydrogen, hydroxy, alkyl, alkoxy, amino, aryl, aralkyl, heterocycloalkyl, heteroaryl, or heteroaralkyl;
• p is 1 or 2;
• and q is 1-4;
• R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, cycloalkenyl, (cycloalkenyl)alkyl, aryl, aralkyl, arylalkenyl, heterocycloalkyl, (heterocycloalkyl)alkyl, heterocycloalkenyl, (heterocycloalkenyl)alkyl, heteroaryl, heteroaralkyl, or (heteroaryl)alkenyl;
• each of A1 and A2, independently, is O, S, N, or NRb;
• provided that at least one of A1 and A2 is N;
• and
• m is 0, 1, 2, or 3;
• provided that when m≧2, two adjacent Ra groups can join together to form a 4- to 8-membered optionally substituted cyclic moiety.