Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy

A pharmaceutical composition for treating hepatitis virus infection, comprising a first amount of an N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compound of Formula I:

• wherein R is selected from the group consisting of straight chain alkyl having a chain length of C7 to C12 and
• W, X, Y, and Z are each independently selected from the group consisting of hydrogen, and butanoyl;
• and
• a second amount of an antiviral compound selected from the group consisting of 2′,3′-dideoxycytidine, 2′,3′-dideoxycytidine-5′-triphosphate, (−)-2′,3′-dideoxy-3′-thiacytidine, (−)-2′-deoxy-3′-thiocytidine-5′-triphosphate, and mixtures thereof and a pharmaceutical acceptable carrier, diluent, or excipient
• wherein said first and second amounts of said compounds together comprise an anti-hepatitis virus effective amount of said compounds.