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US 7,612,088 B2Granted
Heterocyclic compounds and their use as aldosterone synthase inhibitors
AssigneeSpeedel Experimenta AG
InventorsPeter Herold, Robert Mah, Vincenzo Tschinke, Christoph Schumacher, Michael Quirmbach
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Abstract
The application relates to novel heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
Claims11
A compound of the formula
- W is C, or if X is C, is also N;
- X is C or N;
- Y is C;
- Z is a bond;
- R a) is hydrogen;
- or
- b) is C1-C8-alkyl, C1-C8-alkoxy, halogen or trifluoromethyl;
- R1 is C3-C8-cycloalkyl-C0-C4-alkyl or a saturated, 4-8-membered, monocyclic heterocyclyl-C0-C4-alkyl, each of which is unsubstituted or substituted by 1-4 C1-C8-alkoxy, C1-C8-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulfonyl, aryl-C0-C4-alkoxycarbonyl, aryl, cyano, halogen, unsaturated heterocyclyl, oxo, trifluoromethoxy, trifluoromethyl or tri-C1-C4-alkylsilyl, wherein the heterocycle contains 1-3 heteroatoms selected from N, O, and S;
- R2 is hydrogen;
- n is 0-2;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.