7-Polyaminoalkyl(oxy)iminomethylcamptothecins bearing protective groups

Compounds with general formula (I)

• in which
• m is the number 0 or 1;
• Z and Z′ are an integer ranging from 0 to 2 when they are different or are an integer ranging from 1 to 2 when they are the same;
• Y and Y′, which can be the same or different, are (CH2)n1;
• (CH2)n2—CH[NRVII(CH2)n4—NHRI]—(CH2)n3;
• CH2—CH[CH2—CH2]2— or (CH2)n2—N[(CH2)n4—NHRIV]—(CH2)n3;
• Y″ is selected from the group consisting of H;
• cycloalkyl C3-C7;
• (CH2)n5—N[CH2—CH2]2N—(CH2)n6NHRV;
• (CH2)n7 CH[CH2—CH2]2NRV;
• X is O, or is a simple bond;
• n-n7, which can be the same or different, are an integer ranging from 0 to 5;
• RI, RII, RIII, RIV, and RV, which can be the same or different, are a protective group for the nitrogen to which they are bound, said protective group is selected from the group consisting of:
• CO2RVI;
• CO2CH2Ar;
• CO2-(9-fluorenylmethyl);
• (CH2)n5—NH CO2RVI;
• (CH2)n5—NHCO2CH2Ar;
• (CH2)n5—NHCO2-(9-fluorenylmethyl);
• RVI is a straight or branched (C1-C6)alkyl;
• RVII is H or RI-RV;
• Ar is a C6-C12 aromatic residue, such as phenyl, optionally substituted with one or more groups selected from:
• halogen, hydroxy, C1-C5 alkyl, C1-C5 alkoxy, phenyl, cyano, nitro, —NRVIIIRIX, where RVIII and RIX, which can be the same or different, are hydrogen, straight or branched (C1-C5) alkyl, or Ar is a heterocyclic group, said heterocyclic group containing at least one heteroatom selected from a nitrogen atom, optionally substituted with a (C1-C5) alkyl group, and/or oxygen and/or sulphur;
• said heterocycle can be substituted with one or more groups selected from halogen, hydroxy, C1-C5 alkyl, C1-C5 alkoxy, phenyl, cyano, nitro,
• —NRVIIIRIX, where RVIII and RIX, which can be the same or different, are hydrogen, straight or branched (C1-C5) alkyl, the N1-oxides, racemic mixtures, their individual enantiomers, their individual diastereoisomers, the E and Z forms, their mixtures, and pharmaceutically acceptable salts.