US 7,612,079 B2 · 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders

Abstract

The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof wherein R2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R4)CH(R3)OH, wherein R3 is hydrogen or methyl and R4 is methyl, ethyl or isopropyl; R6 is 3-nitrophenylamino, 3,4-dimethoxybenzylamino, 3-iodobenzyl-amino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and or viral disorders.

Claims22

Dependent claims

A compound of formula I

or a pharmaceutically acceptable salt thereof wherein
R2 is 3-hydroxypiperidin-1-yl, or NHCH(R4)CH(R3)OH, wherein R3 is hydrogen or methyl and
R4 is methyl, ethyl or isopropyl;
R6 is 3-nitrophenylamino or indan-5-ylamino;
and
R9 is isopropyl or cyclopentanyl.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/742,237Filed 18 Dec 2003 · continuation

Priority

GB 0115713.027 Jun 2001

Published

US 2005/0009846 A113 Jan 2005

Granted

3 Nov 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 473/16
With oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6: two nitrogen atoms
A61P 17/06
Drugs for dermatological disorders: antipsoriatics
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals

2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders

Life of this patent

2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders

Life of this patent

Abstract

Claims22