Imidazopyridazine compounds

A compound of Formula I

• wherein:
• R0 is hydrogen, halo, methyl or ethyl;
• R1 and R3 are independently methyl, methoxy, or trifluoromethyl;
• R2 is selected from the group consisting of:
• R4 is hydrogen, halo, or hydroxy;
• R5a and R5b are independently ethyl or n-propyl;
• R6 at each occurrence is independently hydrogen, halo, cyano, (C1-C4)alkyl, trifluoromethyl, methoxy, or phenyl;
• R7 is hydrogen, halo, methyl, methoxy, dimethylamino,
• R8 is selected from the group consisting of hydrogen, halo, cyano, (C1-C4)alkyl, RaRbN—, carbamyl, (C1-C2)alkoxy(C1-C2)alkyl, R11—C(O)—,
• R11 is methoxy, methylamino, dimethylamino, or phenyl;
• R12 is hydrogen, halo, methyl, ethyl, trifluoromethyl, methoxy, trifluoromethoxy dimethylamino, acetyl, or methylsulfonyl;
• R13 is hydrogen, methyl or halo;
• R14 is hydrogen or hydroxy;
• R15 is methylthio, cyclopropyl, phenyl,
• Ra is hydrogen, (C1-C5)alkyl, (C3-C5)cycloalkyl, methoxy(C2-C4)alkyl, acetyl, (C1-C2)alkylsulfonyl, (C3)alkenyl, R15—(CH2)n-, or (C1-C2)alkyl substituted with cyano, formyl, vinyl, or ethynyl;
• Rb is hydrogen or (C1-C3)alkyl;
• X is —CH2—, —CO—, —O—, —S— or —SO2—;
• Y is —CH2— or —O—;
• z is S or O;
• n is 1 or 2;
• Q is hydrogen or methyl;
• T is hydrogen or methyl;
• J is methyl, trifluoroethyl, or tert-butyl;
• and
• M is methyl or halo;
• or a pharmaceutically acceptable salt thereof.