Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use

A compound according to formula (I):

• Wherein:
• R1 is an aryl or heteroaryl which is linked to either the α-or β-position to the ring nitrogen;
• R2 is hydrogen, halogen or hydroxy;
• R3 is hydrogen, halogen, C1-10 alkyl, C1-10 heteroalkyl or (R2 and R3) collectively form a C4-7 cycloalkyl, provided that when R3 is halogen, R2 is not hydroxy;
• X is S;
• W is NR5 or CR4R5, wherein R4 is hydrogen, halogen, C1-10 alkyl, or C1-10 heteroalkyl and R5 is C1-10 alkyl or (R4 and R5) collectively form a C4-7 cycloalkyl, provided that when W is NR5, R2 and R3 are hydrogen, C1-10 alkyl or heteroalkyl;
• Y is —COOH, —SH, —N(OH)—CHO or —CO—NH(OH), provided that when Y is —N(OH)CHO or —SH, R2 is hydrogen and R3 is hydrogen, C1-10 alkyl or C1-0 heteroalkyl;
• n is 1;
• or a pharmaceutically acceptable salt thereof.