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US 7,612,046 B2Granted
Method for treating kidney disorders
OwnerUwe Waldemar Rothenpieler, Michael Carl Elmar Imgrundinventors
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OwnerUwe Waldemar Rothenpieler, Michael Carl Elmar Imgrundinventors
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The present invention relates to a cellular therapy of renal failure, i.e. preventing, delaying, and treating acute/chronic renal failure via the use of an effective dose of a substance capable of inducing and/or enhancing Pax2 expression in a mammal for the preparation of a pharmaceutical composition for treating, preventing or delaying a renal dysfunction/failure in a mammal. Additionally, the present invention provides for a method for converting mesenchymal tissue into an epithelial tissue comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax2 expression in mesenchymal tissue and for a method for the regeneration of renal stem cells comprising the administration of an effective amount of a substance capable of inducing and/or enhancing Pax2 expression.
A method for regenerating tubular epithelium in a mammal patient affected by acute tubular necrosis comprising administering directly to the kidney of said mammal patient a therapeutically effective amount of a composition comprising a vector comprising a nucleic acid molecule encoding Pax2a or Pax2b protein, wherein said nucleic acid molecule is operatively linked to an expression control sequence.
A method for generating epithelial cysts from mesenchymal cells in vitro comprising transforming said cells with a vector comprising a nucleic acid molecule encoding Pax2a or Pax2b protein, wherein said nucleic acid molecule is operatively linked to an expression control sequence.
Dependencies are inferred from the claim text.