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US 7,612,039 B2Granted
Method of cell growth inhibition with agnoprotein
AssigneeTemple University of the Commonwealth System of Higher Education
InventorKamel Khalili
Life of this patent
Estimating the term…
Abstract
The growth of normal and abnormally proliferating cells can be inhibited by the introduction of agnoprotein, or biologically active fragments or derivatives of agnoprotein, into the cell in the absence of any other polyoma virus protein or viral replication.
Claims20
A method of inhibiting cell growth comprising introducing into a cell an effective amount of
- (i) an agnoprotein comprising the amino acid sequence of SEQ ID NO:
- 1,
- (ii) one or more biologically active fragments of agnoprotein, wherein said one or more fragments comprise amino acid residues 1-36 of SEQ ID NO:
- 1, or
- (iii) one or more derivatives of agnoprotein, wherein the amino acid sequence of said one or more derivatives have at least about 83% sequence identity to SEQ ID NO:
- 1, and wherein said one or more derivatives have cell growth inhibitory activity, such that growth of the cell is inhibited.
3 more elements
A method of treating a subject having a glioblastoma, comprising administering to the subject an effective amount of
- (i) an agnoprotein comprising the amino acid sequence of SEQ ID NO:
- 1,
- (ii) one or more biologically active fragments of agnoprotein, wherein said one or more fragments comprise amino acid residues 1-36 of SEQ ID NO:
- 1, or
- (iii) one or more derivatives of agnoprotein, wherein the amino acid sequence of said one or more derivatives have at least about 83% sequence identity to SEQ ID NO:
- 1, and wherein said one or more derivatives have cell growth inhibitory activity, such that growth of cells deriving from the glioblastoma is inhibited.
3 more elements
Dependencies are inferred from the claim text.