Composite arrays utilizing microspheres with a hybridization chamber
AssigneeIllumina, Inc.
InventorsJohn Stuelpnagel, Mark Chee, Steven Auger
Life of this patent
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Abstract
The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
Claims76
An array of arrays comprising:
- (a) a first substrate with a surface comprising a plurality of assay wells comprising samples;
- and
- (b) a second substrate comprising a plurality of projections, each projection comprising an array location, each array location comprising a plurality of discrete sites, wherein said sites comprise different bioactive agents, and wherein said first substrate and said second substrate are arranged such that projections of said second substrate are fitted into assay wells of the first substrate.
An array of arrays comprising a plate having wells and a substrate comprising a plurality of projections, each projection comprising an array location, each array location comprising a plurality of discrete sites, wherein said sites comprise different bioactive agents, and wherein projections of said substrate are fitted into wells of said plate.
An array of arrays comprising:
- (a) a first substrate with a surface comprising a plurality of wells;
- and
- (b) a second substrate comprising a plurality of projections, each projection comprising an array location, each array location comprising a plurality of discrete sites, wherein said sites comprise different bioactive agents, and wherein projections of said second substrate are fitted into wells of the first substrate.
An array of arrays comprising:
- (a) a first substrate with a surface comprising a plurality of wells;
- and
- (b) a second substrate comprising a plurality of projections, each projection comprising an array location, each array location comprising a plurality of discrete sites, wherein said sites comprise different bioactive agents, wherein said plurality of projections is configured to be dipped from above into said wells, and wherein said second substrate is not a fiber optic array.
An array of arrays comprising:
- (a) a first substrate with a surface comprising a plurality of wells;
- and
- (b) a second substrate comprising a plurality of projections, each projection comprising an array location, each array location comprising a plurality of discrete sites, wherein said sites comprise different bioactive agents directly coupled thereto, and wherein said plurality of projections is configured to be dipped from above into said plurality of wells.
Dependencies are inferred from the claim text.