US 7,611,884 B2 · Toxoplasma gondii nucleic acid molecules

Abstract

The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules and antibodies. Also included in the present invention are compositions comprising such proteins, nucleic acid molecules and/or antibodies, as well as the use of such compositions to inhibit oocyst shedding by cats due to infection with T. gondii. The present invention also includes the use of certain T. gondii-based antisera to identify such nucleic acid molecules and proteins, as well as nucleic acid molecules and proteins identified by such methods. The present invention also relates to novel methods for the detection of cysts and oocysts.

Claims12

Dependent claims

An isolated nucleic acid molecule selected from the group consisting of:

(a) a nucleic acid molecule that hybridizes to an at least 18 contiguous nucleotide region of SEQ ID NO:72 under conditions comprising (1) hybridizing in a solution comprising 2X SSC in the absence of nucleic acid double helix destabilizing compounds, at a temperature of about 37° C.;
and (2) washing in a solution comprising 1×SSC in the absence of double helix destabilizing compounds at a temperature of about 74° C.;
and
(b) a nucleic acid molecule fully complementary in sequence to the nucleic acid molecule of (a).

1 more element

Dependencies are inferred from the claim text.

Facts

Application

12/138,512Filed 13 Jun 2008 · division

Priority

19 Dec 1997

Published

US 2009/0069264 A112 Mar 2009

Granted

3 Nov 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07K 14/45
From protozoa: toxoplasma
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
A61K 39/00
Medicinal preparations containing antigens or antibodies
A61K 48/00
Medicinal preparations containing genetic material which is inserted into cells of the

Family

Application08/994,825Parent of this continuation-in-part · filed 19 Dec 1997

Application09/216,393Parent of this division · filed 18 Dec 1998

Application10/321,856Parent of this continuation · filed 17 Dec 2002

Application11/321,421Parent of this division · filed 29 Dec 2005

US 2009/0069264 A1Pre-grant publication · published 12 Mar 2009

US 7,396,909 B2Parent of this division

US 7,052,899 B2Parent of this continuation

Application11/321,421Parent of this continuation

US 6,514,694 B2Parent of this division

Application10/321,856Parent of this division

Application09/216,393Parent of this continuation-in-part

US 2001/0014447 A1Published application

US 2003/0194393 A1Published application

US 2006/0115496 A1Published application

US 7,611,884 B2This patent

From the US filing history. Foreign family members aren’t listed.

Toxoplasma gondii nucleic acid molecules

Life of this patent

Toxoplasma gondii nucleic acid molecules

Life of this patent

Abstract

Claims12