Canis sphingosine 1-phosphate receptor isoform 1
AssigneeMerck & Co., Inc.
InventorsSuzanne M. Mandala, Cheryl Meyers, Gan-Ju Maria Shei
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Abstract
A Canis sphingosine-1-phosphate (S1P) receptor isoform 1 (cS1P1), the nucleic acid encoding the cS1P1 receptor, and methods for using the cS1P1 receptor and the nucleic acid encoding the cS1P1 receptor in assays for identifying analytes which modulate activity of the cS1P1 receptor.
Claims9
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a Canis sphingosine-1-phosphate isoform 1 (cS1P1) receptor which comprises the amino acid sequence set forth in SEQ ID NO:2.
An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1.
An isolated protein comprising the amino acid sequence Of SEQ ID NO:2.
A method for identifying an analyte that modulates activity of a Canis sphingosine-1-phosphate receptor isoform 1 (cS1P1) receptor, which comprises:
- (a) providing a recombinant cell comprising an isolated nucleic acid molecule which encodes a cS1P1 receptor comprising the amino acid sequence set forth in SEQ ID NO:
- 2;
- (b) incubating the recombinant cell in a medium with the analyte such that the cell expresses the cS1P1 receptor;
- and
- (c) determining the activity of the cS1P1 receptor wherein a change in the activity of the cS1P1 receptor indicates the analyte modulates activity of the cS1P1 receptor.
Dependencies are inferred from the claim text.