Pharmaceutical composition for transdermal or transmucous administration
AssigneeBesins International Belgique
InventorsBrigitte Taravella, Valėrie Masini-Eteve
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Abstract
The present invention relates to a novel pharmaceutical composition for transdermal or transmucous administration of at least one active substance, and comprising especially a fatty acid as a percutaneous absorption promoter, at least one alcoholic vehicle and also a stabilizer capable of stabilizing the fatty acid in the said pharmaceutical composition.
Claims34
A pharmaceutical composition for transdermal or transmucous administration of at least one active substance, comprising
- an active substance,
- a fatty acid percutaneous absorption promoter in an amount of between 0.1% and 20%, these percentages being expressed on a weight basis relative to 100 g of pharmaceutical composition,
- an alcoholic vehicle comprising an alcohol selected from the group consisting of ethanol and isopropanol, and
- a stabilizer capable of stabilizing the fatty acid in said pharmaceutical composition, wherein said stabilizer comprises the fatty acid ester of said fatty acid and said alcohol and is present in an amount of between 0.1% and 10%, these percentages being expressed on a weight basis relative to 100 g of pharmaceutical composition and
- wherein said composition is in the form of a gel or solution, and
- wherein the amount of said fatty acid percutaneous absorption promoter does not vary by more than +/−5% after storage for 6 months at 40° C. and 75% relative humidity.
A pharmaceutical composition for transdermal or transmucous administration of at least one active substance, comprising
- an active substance,
- oleic acid in an amount of between 0.1% and 20%, these percentages being expressed on a weight basis relative to 100 g of pharmaceutical composition,
- an alcoholic vehicle comprising ethanol, and
- ethyl oleate in an amount of between 0.1% and 10%, these percentages being expressed on a weight basis relative to 100 g of pharmaceutical composition,
- wherein said composition is in the form of a gel or solution, and wherein the amount of oleic acid does not vary by more than +/−5% after storage for 6 months at 40° C. and 75% relative humidity.
A method of making a pharmaceutical composition for transdermal or transmucous administration of at least one active substance, comprising admixing:
- an active substance,
- a fatty acid percutaneous absorption promoter in an amount of between 0.1% and 20%, these percentages being expressed on a weight basis relative to 100 g of pharmaceutical composition,
- an alcoholic vehicle comprising an alcohol selected from the group consisting of ethanol and isopropanol, and
- a stabilizer capable of stabilizing the fatty acid in said pharmaceutical composition, wherein said stabilizer comprises the fatty acid ester of said fatty acid and said alcohol and is present in an amount of between 0.1% and 10%, these percentages being expressed on a weight basis relative to 100 g of pharmaceutical composition,
- wherein said composition is in the form of a gel or solution.
Dependencies are inferred from the claim text.