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US 7,611,721 B1Granted
Adjuvant combination formulations
AssigneeWyeth Holdings Corporation
InventorMichael Hagen
Life of this patent
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Abstract
The use of 3-O-deacylated monophosphoryl lipid A or monophosphoryl lipid A and derivatives and analogs thereof, in combination with a cytokine or lymphokine such as granulocyte macrophage colony stimulating factor or interleukin-12 is useful as an adjuvant combination in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen.
Claims55
An antigenic composition consisting of an antigen and an effective adjuvanting amount of the combination of:
- (1) 3-O-deacylated monophosphoryl lipid A or monophosphoryl lipid A, and (2) granulocyte macrophage colony stimulating factor (GM-CSF), together with a diluent or carrier.
Dependencies are inferred from the claim text.