Glycoprotein VI antibodies and methods thereof
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsNarendra Nath Tandon, Yutaka Matsumoto, Hisao Takizawa, Keiji Okuyama
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Abstract
The present invention describes antibodies generated against platelet membrane glycoprotein VI-(GPVI), methods of producing the anti-GPVI antibodies, and the use of these antibodies as research and immunotherapeutic agents, in particular, as antithrombotic therapeutic agents.
Claims8
A monoclonal antibody specific for a glycoprotein VI (GPVI) polypeptide or peptide, wherein the monoclonal antibody inhibits collagen-induced platelet aggregation at an IC50 of less than 7 μg/ml, wherein the IC50 is determined using a concentration of collagen that induces 70-90% platelet aggregation within 5 minutes of its contact with platelets in a platelet aggregation assay, wherein the monoclonal antibody specifically binds to a GPVI polypeptide or peptide at a Kd of lower than 10−8M, and wherein the monoclonal antibody is selected from OM1 (ATCC No. PTA-5938), OM2 (ATCC No. PTA-5939), OM3 (ATCC No. PTA-5940), and OM4 (ATCC No. PTA-5941).
Dependencies are inferred from the claim text.