Mechanism-based targeted pancreatic beta cell imaging and therapy
AssigneeBoard of Regents, The Univerisity of Texas System
InventorsDavid J. Yang, Chang-Sok Oh, Saady Kohanim, Dong-Fang Yu, Ali Azhdarinia, Jerry Bryant
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Abstract
Compositions for imaging pancreatic beta cells comprise chelator-antidiabetic agent conjugates and optionally chelated metals.
Claims10
A method of monitoring pancreatic beta cell mass or morphology in a mammal comprising administering to the mammal a composition comprising diethylenetriamine pentaacetic acid (DTPA)-nateglinide, diethylenetriamine pentaacetic acid (DTPA)-glipizide, diethylenetriamine pentaacetic acid (DTPA)-glyburide or diethylenetriamine pentaacetic acid (DTPA)-glimepiride and a chelated metal ion and imaging the pancreas.
A method of monitoring pancreatic beta cell mass or morphology in a mammal comprising administering to the mammal a composition comprising 99mTc-DTPA-glipizide and imaging the pancreas.
Dependencies are inferred from the claim text.