Nanoparticles for protein drug delivery
AssigneesGP Medical, Inc., National Tsing Hua University
InventorsHsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
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Abstract
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
Claims17
A pharmaceutical composition of nanoparticles for oral administration in a patient, said nanoparticles comprising a shell portion that is dominated by positively charged chitosan, a core portion that consists of one negatively charged substrate, wherein said substrate is PGA, wherein said negatively charged substrate is at least partially neutralized with a portion of said positively charged chitosan in the core portion, and at least one bioactive agent loaded within said nanoparticles, wherein said at least one bioactive agent comprises incretin mimetics or pramlintide.
Dependencies are inferred from the claim text.