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AssigneeAperon Biosystems Corp.
InventorsDavid J. Anvar, David J. Chazan, Bryan P. Flaherty, Bhairavi R. Parikh
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Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.
In a device for detecting nitric oxide in a gas sample, said device comprising a sensor that binds both said nitric oxide and carbon monoxide and undergoes a detectable change when bound to said nitric oxide, said sensor retained in a housing that is constructed of or further retains a carbon monoxide-releasing material, the improvement in which said device further comprises a carbon monoxide scavenger retained within said housing or within packaging enclosing said housing and is confined to a localized region that is removed from said sensor by a distance of about 3 mm to about 300 mm, such that any variation in nitric oxide detection caused by said scavenger is less than the greater of 1 ppb of nitric oxide or 10% of the level of nitric oxide detected.
In a device for detecting nitric oxide in a gas sample, said device comprising a sensor that binds both said nitric oxide and carbon monoxide and undergoes a detectable change when bound to said nitric oxide, said sensor retained in a housing that is constructed of or further retains a carbon monoxide-releasing material, the improvement in which said device further comprises a carbon monoxide scavenger separated from said sensor by a flow-restricting orifice that limits any variation in nitric oxide detection caused by said scavenger to less than the greater of 1 ppb of nitric oxide or 10% of the level of nitric oxide detected.
In a device for detecting nitric oxide in a gas sample, said device comprising a sensor that binds both said nitric oxide and carbon monoxide and undergoes a detectable change when bound to said nitric oxide, said sensor retained in a housing that is constructed of or further retains a carbon monoxide-releasing material, the improvement in which said device further comprises a carbon monoxide scavenger separated from said sensor by a diffusion-lowering membrane that limits any variation in nitric oxide detection caused by said scavenger to less than the greater of 1 ppb of nitric oxide or 10% of the level of nitric oxide detected.
In a device for detecting nitric oxide in a gas sample, said device comprising a NO sensor consisting of cytochrome C encapsulated in a sol gel matrix and retained in a housing that is constructed of or further retains a carbon monoxide-releasing material, the improvement in which said device further comprises a carbon monoxide scavenger retained within said housing or within packaging enclosing said housing.
Dependencies are inferred from the claim text.