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US 7,611,647 B2Granted
Process for the selective deprotonation and functionalization of 1-fluoro-2-substituted-3-chlorobenzenes
AssigneeDow AgroSciences LLC
InventorsKim E. Arndt, Mark V. M. Emonds, James M. Renga, Jossian Oppenheimer
Life of this patent
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Abstract
1-Fluoro-2-substituted-3-chlorobenzenes are selectively deprotonated and functionalized in the position adjacent to the fluoro substituent.
Claims7
A process for the preparation of a lithiobeuzene of Formula I
- wherein
- X represents F, OR1 or NR2R3;
- Y represents H or F;
- and
- R1, R2 and R3 independently represents a C1-C4 alkyl group;
- which comprises contacting a substituted fluorobenzene of Formula II
- wherein X, Y, R1, R2 and R3 are as previously defined with an alkyl lithium in an inert organic solvent.
4 more elements
A compound of the formula
- wherein
- X represents OR1 or NR2R3;
- Y represents H or F;
- Z represents —CO2;
- and
- R1, R2 and R3 independently represents a C1-C4 alkyl group.
3 more elements
Dependencies are inferred from the claim text.