Disposable oxygen sensor and method for correcting oxygen effect on oxidase-based analytical devices

A system for correcting the oxygen effect on oxidase-based analyte sensors, said system comprising:

• an oxygen sensor comprising a working electrode, a reference electrode and a reagent matrix disposed on at least said working electrode wherein said reagent matrix contains a reduced form of a redox mediator, an oxidase and a peroxidase wherein said oxygen sensor has a known correlation between oxygen concentration and analyte concentration expressed as a function of the response of said oxygen sensor to both oxygen and an analyte wherein said analyte is a substrate of said oxidase;
• an oxidase-based analyte sensor for measuring an analyte in a portion of a fluid sample wherein said analyte is a substrate of said oxidase in said oxygen sensor and wherein the correlation between oxygen concentration and oxygen effect on said oxidase-based analyte sensor is known;
• means for electronically determining an oxygen concentration in a portion of said fluid sample using said oxygen sensor;
• means for electronically determining an analyte concentration in another portion of said fluid sample using said oxidase-based analyte sensor;
• and
• means for using said determined oxygen concentration in said fluid sample to determine a corrected value of said analyte concentration in said fluid sample.

A combination for correcting the oxygen effect on oxidase-based analyte sensors, the combination comprising:

• a disposable sensor strip comprising:
• an oxygen electrode with an oxygen reagent matrix disposed thereon, said oxygen reagent matrix includes a reduced form of a redox mediator, an oxidase and a peroxidase wherein said oxygen sensor has a known correlation between oxygen concentration and analyte concentration expressed as a function of the response of said oxygen sensor to both oxygen and an analyte wherein said analyte is a substrate of said oxidase;
• an oxidase-based analyte electrode with an oxidase-based reagent matrix thereon, said oxidase-based reagent matrix includes an oxidized form of a redox mediator and an enzyme capable of catalyzing a reaction involving a substrate for said oxidase of said oxygen electrode and wherein the correlation between oxygen concentration and oxygen effect on said oxidase-based analyte sensor is known;
• a reference electrode;
• and
• a sample chamber containing said oxygen electrode, said oxidase-based analyte electrode and said reference electrode;
• and
• meter means for electronically coupling said oxygen electrode and said reference electrode to measure an oxygen concentration in a sample fluid, for electronically coupling said oxidased-based analyte electrode to said reference electrode to measure an analyte concentration in said sample fluid, and for electronically calculating a corrected analyte concentration in said fluid sample using said measured oxygen concentration.