Multi-drug titration and evaluation

A method for titrating a multi-modality therapy regimen in an individual patient, comprising performing multiple times the steps of:

• i) providing p modalities to said individual patient in a plurality of dose combinations;
• ii) measuring a clinical endpoint in said individual patient;
• iii) assigning, using said computer, said measurements obtained in said measuring step to a desirability function;
• iv) associating, using said computer, said measurements obtained in said measuring step for said clinical endpoint with a vertex of a geometric figure, wherein said geometric figure has vertices, and wherein each of said vertices represents one of said plurality of dose combinations;
• and
• v) outputting, using said computer, a next dose combination for said individual patient by applying an evolutionary operation direct search algorithm to said geometric figure, and
• vi) performing steps i)-v) multiple times, wherein performing steps i)-v) multiple times constitutes titration of said multi-modality therapy regimen in said individual patient;
• and wherein results of said method are shown, displayed or represented as a plot, table or geometric representation, which enables a physician or researcher to evaluate and adjust said multi-modality therapy regimen for said individual patient.

A method for titrating a multi-modality therapy regimen in a plurality of patients, comprising the steps of:

• i) providing p modalities to an individual patient in a plurality of dose combinations;
• ii) measuring a clinical endpoint in said individual patient;
• iii) assigning, using a computer, measurements obtained in said measuring step to a desirability function;
• iv) associating, using said computer, said measurements made obtained in said measuring step for said clinical endpoint with a vertex of a geometric figure, wherein said geometric figure has vertices, wherein each of said vertices represents one of said plurality of dose combinations;
• and
• v) determining, using said computer, a next dose combination for said individual patient by applying an evolutionary operation direct search algorithm to said geometric figure, and
• vi) performing steps i)-v) multiple times, wherein said step of performing each of said steps constitutes titration of said multi-modality therapy regimen in said individual patient;
• and wherein results of said method are shown, displayed or represented as a plot, table or geometric representation, which enables a physician or researcher to evaluate and adjust said multi-modality therapy regimen for said individual patient;
• vii) performing said steps i)-vi) of said method in each individual in said plurality of patients;
• viii) constructing, using said computer, a confidence ellipsoid about a central location of final dose combinations for said plurality of patients in p-dimensional dose space;
• and ix) evaluating said confidence ellipsoid to determine
• whether a combination of p modalitites is better than no treatment at all;
• or
• whether a combination of p modalities is better than a combination of fewer than p modalities.