Methods for treating central nervous system damage
AssigneeWashington University
InventorJohn W. McDonald, III
Life of this patent
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Abstract
Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the control of which has been affected by the CNS damage. The induction of FES-evoked patterned movement at least partially restores lost motor and sensory function, and stimulates regeneration of neural progenitor cells in the subject patient.
Claims26
A method for treating multiple sclerosis central nervous system (CNS) damage in a mammalian subject in need of such treatment comprising
- inducing a therapeutically effective amount of functional electrical stimulation (FES)-evoked patterned movement in a mammalian subject for a period of time sufficient to regenerate neural cells;
- and
- monitoring the mammalian subject for CNS neural regeneration or CNS motor function;
- wherein
- the patterned movement occurs during exposure to FES;
- and
- at least a portion of lost motor function or sensory function of the mammalian subject lost is restored.
A method for treating central nervous system (CNS) damage in a mammalian subject in need of such treatment comprising
- inducing a therapeutically effective amount of functional electrical stimulation (FES)-evoked patterned movement in a mammalian subject for a period of time sufficient to regenerate neural cells;
- and
- monitoring the mammalian subject for CNS neural regeneration or CNS motor function;
- wherein
- the patterned movement occurs during exposure to FES;
- at least a portion of lost motor function or sensory function of the mammalian subject lost is restored;
- and
- the CNS damage comprises (i) an acute trauma selected from the group consisting of complete severance of the spinal cord, partial severance of the spinal cord, and stroke or (ii) a chronic disease selected from the group consisting of multiple sclerosis, cancer, tumor metastasis, Huntington's Disease, Alzheimer's disease, amyotrophic lateral sclerosis, and neurodegenerative effects of aging.
Dependencies are inferred from the claim text.