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US 7,610,074 B2Granted
Multi-functional plasmon-resonant contrast agents for optical coherence tomography
AssigneesThe Board of Trustees of the University of Illinois, Purdue Research Foundation
InventorsStephen A. Boppart, Alexander Wei
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Abstract
A method of forming an image of a sample, comprising: forming an image of a mixture, by exposing the mixture to electromagnetic radiation; wherein the mixture comprises the sample and plasmon-resonant nanoparticles, and wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.
Claims13
A method of forming an image by optical coherence tomography, comprising:
- forming an image of a mixture by exposing the mixture to electromagnetic radiation;
- wherein the mixture comprises a patient and plasmon-resonant nanoparticles, wherein the electromagnetic radiation is provided to the mixture using optical coherence tomography in the frequency range of infra-red to ultraviolet light, and wherein the plasmon-resonant nanoparticles are anisotropic metallic nanoparticles having an extinction coefficient of at least 106M−1cm−1 at a frequency in the range of 1012 to 1017 Hz, wherein the anisotropic metallic nanoparticles comprise a magnetic metal, and wherein the magnetic metal is selected from nickel, cobalt, iron, and combinations thereof.
A method of forming an image by optical coherence tomography, comprising:
- administering to a patient, anisotropic metallic nanoparticles having an extinction coefficient of at least 106M−1cm−1 at a frequency in the range of 1012 to 1017 Hz;
- wherein the anisotropic metallic nanoparticles are gold nanorods with a magnetic tip, and wherein the magnetic tip is one metal selected from the group consisting of cobalt, nickel, and iron;
- exposing the patient to electromagnetic radiation;
- collecting reflected electromagnetic radiation;
- and
- forming an enhanced contrast image from the collected electromagnetic radiation.
3 more elements
Dependencies are inferred from the claim text.