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US 7,609,731 B2Granted
Laser system using ultra-short laser pulses
AssigneeBoard of Trustees operating Michigan State University
InventorsMarcos Dantus, Vadim V. Lozovoy, Matthew Comstock
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Abstract
A laser system using ultrashort laser pulses is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal.
Claims99
A system comprising:
- a) a laser operable to emit a femtosecond laser beam pulse;
- b) a phase shaper operable to shape the pulse with binary phase values;
- and
- c) a controller operable to automatically control the laser and the shaper, the controller including software instructions operable causing and controlling multiphoton intrapulse interference in the laser beam pulse.
1 more element
A system comprising:
- a) a laser beam pulse;
- b) a phase shaper operable to shape the laser beam pulse with encoded characteristics and with binary phase value;
- c) a nonlinear optical medium operable to separate multiple frequencies of the pulse;
- d) software instructions operable causing and controlling multiphoton intrapulse interference in the laser beam pulse;
- e) a detection device operable to detect the characteristics of the shaped laser beam pulse as separated by the nonlinear optical medium;
- and
- f) a unit connected to the device operably decoding the characteristics.
4 more elements
A system for use with living tissue, the system comprising:
- a high peak intensity laser beam pulse;
- software instruction operable causing and controlling multiphoton intrapulse interference in the laser beam pulse;
- a device operable to change a characteristic of the pulse prior to emission of the pulse upon the living tissue through use of multiphoton intrapulse interference;
- and
- wherein nonlinear transitions induced by each pulse are controlled by binary phase shaping and the software instructions.
2 more elements
A system for multiphoton microscopy, the system comprising:
- a) a femtosecond laser operable to emit a laser pulse;
- b) a target operable to hold a sample in the pulse;
- c) the sample operably labeled with at least one fluorescent probe;
- d) software instructions operable causing and controlling multiphoton intrapulse interference in the pulse;
- e) a phase shaper operable to shape the pulse in the binary manner to cause selective excitation of the probe and to correct for phase distortions;
- and
- f) a detector operably detecting an emission from the sample.
4 more elements
A method for microscopy of a target material containing probes that are excitable by multiphoton multi-photon excitation, the method comprising:
- a) generating a laser pulse;
- b) using programmable instructions to cause and control multiphoton intrapulse interference in the pulse;
- c) shaping the pulse using a binary phase shaper employing binary phase functions so that the pulse selectively excites a desired probe by the multiphoton excitation;
- d) directing the shaped pulse at the target;
- and
- e) detecting emissions from the target.
3 more elements
A method of pulse shaping, the method comprising:
- a) emitting a laser pulse having a duration less than 110 femtoseconds;
- b) directing the pulse into a pulse shaper;
- c) characterization of the pulse using multiphoton intrapulse interference phase software, the software including instructions operable causing and controlling multiphoton intrapulse interference in the pulse if desired;
- and
- d) shaping the pulse by only two phase values.
2 more elements
A method of pulse shaping, the method comprising:
- a) emitting at least one laser pulse;
- b) directing the at least one pulse into a pulse shaper;
- c) shaping the at least one pulse in a binary manner and
- d) characterization of the at least one pulse using multiphoton intrapulse interference phase scan software, the software including instructions operable to cause and control multiphoton intrapulse interference in the pulse if desired.
1 more element
A system comprising:
- a laser operably emitting at least one laser beam pulse of less than 51 femtoseconds;
- a pulse shaper operably controlling a spectral phase of the at least one pulse, the shaper shaping the at least on pulse by only two phase values;
- a detector operably detecting a spectrally dispersed second harmonic of the at least one shaped pulse;
- and
- a controller connected to the shaper and detector, the controller operably controlling multiphoton intrapulse interference in the at least one pulse, the controller being operable to use software instructions to cause and control multiphoton intrapulse interference in the at least one pulse.
2 more elements
A system comprising:
- (a) a laser emitting a laser beam pulse;
- (b) a shaper operably shaping the pulse with binary phase values;
- and
- (c) a controller including software instructions being operable to cause and control multiphoton intrapulse interference in the pulse with the assistance of the binary phase values.
1 more element
Dependencies are inferred from the claim text.