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US 7,608,731 B2Granted
Phenylacetic acid compounds
AssigneeRoche Palo Alto LLC
InventorsDenis John Kertesz, Michael Martin, Wylie Solang Palmer
Life of this patent
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Abstract
The present invention provides a process for the preparation 6-[3-(hetero)aryloxy-2-fluoro-benzyl]-2H-pyridazin-3-one compounds 1 where R2 is an optionally substituted aryl or an optionally substituted heteroaryl, R6 is NO2, NH2, alkyl, halogen, or a function group readily derived therefrom and R4c is hydrogen or alkyl. There also is provided a process for the preparation of phenylacetic acid compounds 2, wherein R2 and R6 are as defined previously and R5a is hydrogen or alkyl, which are useful for the preparation of pyridazinone compounds.
Claims1
A compound according to formula Va wherein:
- R2 is an aryl radical and said aryl radical is optionally substituted with zero to three substituents independently selected from the group consisting of C1-6 alkyl, C1-6 alkenyl, C1-6 haloalkyl, C3-8 cycloalkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 sulfonyl, C1-6 haloalkoxy, C1-6 haloalkylthio, hydroxyl, halogen, amino, C1-6 alkylamino, C1-6 dialkylamino, C1-6 N,N-dialkylcarbamoyl, nitro and cyano;
- R4a is in each occurrence is independently hydrogen, C1-6 alkyl or benzyl;
- R5 is H or CO2R5a:
- and
- R5a is independently in each occurrence a straight or branched C1-6 alkyl.
2 more elements
Dependencies are inferred from the claim text.