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US 7,608,722 B2Granted
Preparation of 1,7,′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole
AssigneeBoehringer Ingelheim International GmbH
InventorsHelmut Heitger, Juan M. Rodriguez-Dehli, Rolf Dach
Life of this patent
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Abstract
A process for preparing 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole of formula (I) reacting N-methyl-o-phenylenediamine of formula (II) or the salts thereof with 2-propyl-4-methyl-1H-benzimidazole-6-carboxylic acid of formula (III) or the salts thereof wherein the coupling and cyclization is achieved using 1,3,5-triazine and tertiary amine.
Claims8
A process for preparing 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole of formula (I)
- reacting N-methyl-o-phenylenediamine of formula (II) or the salts thereof
- with 2-propyl-4-methyl-1H-benzimidazole-6-carboxylic acid of formula (III) or the salts thereof
- wherein the coupling and cyclization is achieved using 1,3,5-triazine and tertiary amine.
Dependencies are inferred from the claim text.