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US 7,608,721 B2Granted
Hexafluoroisopropanol derivatives
AssigneeHoffmann-La Roche Inc.
InventorsHenrietta Dehmlow, Bernd Kuhn, Raffaello Masciadri, Narendra Panday, Hasane Ratni, Matthew Blake Wright
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Abstract
The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
Claims17
A compound of the formula (I):
- wherein:
- R1 is hydrogen, halogen, or lower-alkyl;
- R2 is lower-alkyl, fluoro-lower-alkyl, cycloalkyl-lower-alkyl, or heterocyclyl-lower-alkyl;
- R3 is hydrogen, lower-alkyl, aryl, cycloalkyl, or heterocyclyl;
- R4 is hydrogen, hydroxy, lower-alkoxy, aryl-lower-alkoxy, or heterocyclyl-lower-alkoxy;
- R5 is hydrogen, lower-alkyl, aryl, or heterocyclyl;
- R6 is heterocyclyl;
- m is 0 to 3;
- n is 0 or 1;
- and pharmaceutically acceptable salts and esters thereof.
7 more elements
Dependencies are inferred from the claim text.