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US 7,608,717 B2Granted
Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands
AssigneeWyeth
InventorsDerek Cecil Cole, Ronald Charles Bernotas
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Abstract
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
Claims9
A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and an effective amount of a compound of formula I
- wherein
- Q is —(CR2R3)n—NR4R5,
- W is N;
- X is CR7;
- Y is CR8;
- Z is CR9;
- R is an optionally substituted aryl or heteroaryl group or an optionally substituted 8-membered bicyclic ring system having a N atom at the bridgehead and containing 2 additional heteroatoms selected from N or S wherein said ring system is an imidazothiazole ring;
- R7, R8 and R9 are each independently H;
- R2 and R3 are each independently H or an optionally substituted C1-C6alkyl group;
- n is an integer of 2, 3, 4 or 5;
- p is 0 or an integer of 1 or 2
- R4 and R5 are each independently H or a C1-C6alkyl group;
- R6 is H or an optionally substituted C1-C6alkyl group;
- and
- represents a single bond or a double bond;
- or
- a stereoisomer thereof or a pharmaceutically acceptable salt thereof.
14 more elements
Dependencies are inferred from the claim text.