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US 7,608,711 B2Granted
Process for the preparation of ziprasidone
AssigneeDipharma Francis S.R.L.
InventorsJacopo Zanon, Oscar Martini, Francesco Ciardella, Luca Gregori, Federico Sbrogio, Andrea Castellin
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Abstract
A process for the preparation of ziprasidone and a novel intermediate useful in its preparation. The process comprises the reduction of a compound (III) to give a compound (V) which is then reduced to compound (II). This is reacted with compound (IV) to give the desired compound.
Claims5
A process for the preparation of ziprasidone (I) or a pharmaceutically acceptable salt thereof,
- which comprises
- a) reducing a compound (III)
- by treatment with an alkali metal borohydride to yield a compound (V)
- b) reducing compound (V) to yield a compound (II)
- c) reacting compound (II) with a compound (IV)
- d) and, if desired, converting compound (I) to a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.