Corticotropin releasing factor 2 receptor agonists
AssigneeThe Procter & Gamble Company
InventorsRobert Joseph Isfort, Wieslaw Adam Mazur
Life of this patent
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Abstract
Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.
Claims21
An isolated nucleic acid encoding a non-native peptide, wherein the non-native peptide comprises the sequence
- ZGPPISIDLPX11X12LLRKX17IEIEKQEKEKQQAX31X32NAX35X36LX38X39X40 (SEQ ID NO:
- 531);
- wherein:
- X11 is selected from F, Y, L, I, and T;
- X12 is selected from Q, W, and Y;
- X17 is selected from V and M;
- X31 is selected from T and A;
- X32 is selected from N and T;
- X35 is selected from R and L;
- X36 is selected from L and I;
- X38 is selected from D and A;
- X39 is selected from T and R;
- and
- X40 is selected from I and V;
- and variants thereof having at least 95% sequence identity to said peptide.
An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence of SEQ ID NO:
- 278, and variants thereof having at least 95% sequence identity to said non-native peptide.
An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence
- ZGPPISIDLPX11X12LLRKX17IEIEKQEKEKQQAX31X32NAX35X36LX38X39X40 (SEQ ID NO:
- 531);
- wherein:
- X11 is selected from F, Y, L, I, and T;
- X12 is selected from Q, W, and Y;
- X17 is selected from V and M;
- X31 is selected from T and A;
- X32 is selected from N and T;
- X35 is selected from R and L;
- X36 is selected from L and I;
- X38 is selected from D and A;
- X39 is selected from T and R;
- and
- X40 is selected from I and V.
An isolated nucleic acid encoding for a non-native peptide, wherein the non-native peptide comprises the sequence of SEQ ID NO:
- 278.
Dependencies are inferred from the claim text.