Loading patent…
AssigneeAjinomoto Co., Inc.
InventorsNaoyuki Fukuchi, Fumie Futaki, Morikazu Kito, Seiichi Sato, Takayuki Kajiura, Yukitsugu Ono, Koichi Ishii, Akiko Tanaka, Junko Shinozaki, Yasuko Jojima
Estimating the term…
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric protein constructed by fusing the carboxyl terminal of a partial protein containing the von Willebrand factor-binding site of glycoprotein Ib with the amino terminal of the Fc region of an immunoglobulin molecule. Then the Fc region of the above immunoglobulin molecule is detected to thereby detect the binding between the von Willebrand factor and the glycoprotein Ib or inhibition of this binding.
A chimeric protein, which consists of an Fc region of immunoglobulin molecule fused at its amino terminus to a partial protein of glycoprotein Ibα chain at its carboxyl terminus,
A kit for measuring glycocalicin based on inhibition of a reaction of von Willebrand factor and glycoprotein Ib, comprising von Willebrand factor and a chimeric protein that consists of an Fc region of immunoglobulin molecule fused at its amino terminus to a partial protein of glycoprotein Ibα chain at its carboxyl terminus,
A chimeric protein, which consists of an Fc region of immunoglobulin molecule fused at its amino terminus to a partial protein of glycoprotein Ibα chain at its carboxyl terminus,
A kit for measuring glycocalicin based on inhibition of a reaction of von Willebrand factor and glycoprotein Ib, comprising von Willebrand factor and a chimeric protein that consists of an Fc region of immunoglobulin molecule fused at its amino terminus to a partial protein of glycoprotein Ibα chain at its carboxyl terminus,
A chimeric protein, which consists of an Fc region of immunoglobulin molecule fused at its amino terminus to a partial protein of glycoprotein Ibα chain at its carboxyl terminus,
A kit for measuring glycocalicin based on inhibition of a reaction of von Willebrand factor and glycoprotein Ib, comprising von Willebrand factor and a chimeric protein that consists of an Fc region of immunoglobulin molecule fused at its amino terminus to a partial protein of glycoprotein Ibα chain at its carboxyl terminus,
Dependencies are inferred from the claim text.