Pharmaceutical compositions comprising cross-linked small molecule amine polymers

A pharmaceutical composition comprising a particulate crosslinked amine polymer as an active ingredient and a pharmaceutically acceptable excipient, the particulate crosslinked amine polymer particles having a chloride content of less than about 20 mol % of the amine group content and a size in the range of 5 to 500 microns, the crosslinked amine polymer comprising repeat units derived from polymerization of a non- polymeric amine and a crosslinking agent such that the polymer has a swelling ratio of less than about 5 as measured in a physiological medium, the non-polymeric amine being selected from the group consisting of

• (i) a non-polymeric amine of formula (I)
• wherein each n, independently, is equal to or greater than 3;
• m is equal to or greater than 1;
• and each R1, independently, is H or optionally substituted alkyl or aryl or is linked to a neighboring R1 to form an optionally substituted alicyclic, aromatic, or heterocyclic group;
• provided the non-polymeric amine of formula I is not 1,3-diaminopropane, and
• (ii) a non-polymeric amine of formula (IV)
• wherein each n, independently, is equal to or greater than 3;
• each r, independently, is 0, 1, or 2;
• and each R1, independently, is H or optionally substituted alkyl or aryl or is linked to a neighboring R1 to form an optionally substituted alicyclic, aromatic, or heterocyclic group.