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US 7,608,622 B2Granted
Imidazo[4,5-b]pyrazinone inhibitors of protein kinases
AssigneeJanssen Pharmaceutica NV
InventorsJian Liu, Raymond J. Patch, Mark R. Player, Huaping Hu
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Abstract
The invention is directed to compounds of Formula I: wherein Q, Y, A are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein kinases, especially Aurora-1, Aurora-2 and Aurora-3 kinases.
Claims6
A compound of Formula I:
- a stereoisomeric or tautomeric form thereof or a pharmaceutically acceptable salt thereof, wherein
- Q is a direct link or C1-6alkylene;
- Y is phenyl, naphthyl, indanyl, thienyl, pyridinyl, or benzofuranyl, each of which may be optionally substituted with one, two, or three substituents selected from the group consisting of C1-4alkyl, nitro, amino, halogen, cyano and metboxy;
- A is phenyl, pyridinyl, indolyl, isoxazolyl or thienyl, each of which may be optionally substituted with one to three substituents selected from the group consisting of C1-6alkyl, halogen, hydroxy, hydroxyC1-6alkyl, C1-6alkoxy and carboxyl.
1 more element
Dependencies are inferred from the claim text.