Process for preparing macrocyclic compounds

A compound of the following formula QUIN:

• wherein:
• L0 selected from H, —OH, —OCH3, —OC2H5, —OC3H7, —OCH(CH3)2, —NHCH3, —NHC2H5, —NHC3H7, —NHCH(CH3)2, —N(CH3)2, —N(CH3)C2H5, —N(CH3)C3H7 and —N(CH3)CH(CH3)2,
• L1 and L2 are each independently selected from hydrogen, fluorine, chlorine, bromine, —CH3, —C2H5, —C3H7, —CH(CH3)2, —OCH3, —OC2H5, —OC3H7 and —OCH(CH3)2,
• R2 is C1-6 thioalkyl, C1-6 alkoxy, or Het, where Het is selected from the following:
• wherein R6 is H, C1-6 alkyl, NH—R7, NH—C(O)—R7, or NH—C(O)—NH—R7,
• wherein each R7 is independently:
• H, C1-6 alkyl, or C3-6 cycloalkyl;
• or R6 is NH—C(O)—OR8, wherein R8 is C1-6 alkyl;
• and R is a C6 or C10 aryl group.