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AssigneeInfinity Pharmaceuticals, Inc.
InventorsJulian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
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The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula:
A compound of the formula:
A pharmaceutical composition comprising an antioxidant, a metal chelator, a buffering agent, and a compound of the formula:
A pharmaceutical composition comprising L-ascorbic acid, ethylenediamine tetraacetic acid (EDTA) disodium calcium dihydrate, citric acid monohydrate, and a compound of the formula:
Dependencies are inferred from the claim text.