Use of lipid conjugates in the treatment of conjunctivitis
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorSaul Yedgar
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Abstract
In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof to a subject with conjunctivitis.
Claims13
A method of treating conjunctivitis in a subject comprising the step of contacting said subject with a compound represented by the structure of the general formula 1):
- wherein
- R1 is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain ranging in length from 2 to 30 carbon atoms;
- R2 is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain ranging in length from 2 to 30 carbon atoms;
- and
- Y is either nothing or a spacer group ranging in length from 2 to 30 atoms;
- X is a physiologically acceptable monomer, dimer, oligomer, or polymer, and wherein
- X is a glycosaminoglycan;
- and
- n is a number from 1 to 1000;
- wherein if Y is nothing the phosphatidylethanolamine is directly linked to X via an amide bond and if Y is a spacer, said spacer is directly linked to X via an amide or an esteric bond and to said phosphatidylethanolamine via an amide bond and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
Dependencies are inferred from the claim text.