Calcitonin drug-oligomer conjugates, and uses thereof
AssigneeBiocon Limited
InventorsNnochiri N. Ekwuribe, Balasingam Radhakrishnan
Life of this patent
Estimating the term…
Abstract
Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.
Claims13
A substantially monodispersed calcitonin oligomer conjugate mixture consisting of a salmon or human calcitonin coupled to two oligomer subunits, wherein each oligomer comprises a polyalkylene glycol moiety, wherein the conjugate consists of a first oligomer subunit and a second oligomer subunit wherein the first oligomer subunit is covalently coupled to Lys11 of the calcitonin drug and the second oligomer subunit is covalently coupled to Lys18 of the calcitonin drug, wherein the substantially monodispersed calcitonin drug-oligomer conjugate consisting of the structure of Formula I:
- wherein
- x is an integer from 5 to 9;
- y is an integer from 4 to 10;
- and
- z is 2 which is the number of conjugation sites on the calcitonin.
Dependencies are inferred from the claim text.