Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
AssigneesGenetics Institute, Inc., Fidia Advanced Biopolymers S.r.l.
InventorsHyun Kim, Rebecca Li, Alessandra Pavesio, Lanfranco Callegaro, Howard Seeherman, John Wozney
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Abstract
An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
Claims15
A method for promoting bone, cartilage, or tendon formation in a patient comprising injecting an osteogenic composition through the skin of the patient to a site in need of bone formation, wherein the composition comprises
- (a) an osteogenic protein,
- (b) an injectable hyaluronic acid ester, and
- (c) a pore former selected from a liquid pore former or sodium bicarbonate.
A method for promoting the attachment of ligament to bone in a patient comprising injecting an osteogenic composition through the skin of the patient to a site in need of attachment, wherein the composition comprises
- (a) an osteogenic protein,
- (b) an injectable hyaluronic acid ester, and
- (c) a pore former selected from a liquid pore former or sodium bicarbonate.
Dependencies are inferred from the claim text.