Lung volume reduction using glue compositions

A method of reducing lung volume in a lung of a subject in need thereof comprising:

• providing a glue composition comprising a first adhering moiety connected via an amide bond linkage to a first site on a chemical linker, and a second adhering moiety which is connected via an amide bond to a second site on said chemical linker, wherein the chemical linker comprises a functional group selected from the group consisting of a carboxyl group and an amine group, and wherein said first and second adhering moieties adhere to different sites bearing elastase in a lung, and are independently selected from the group consisting of a) alpha-1 antitrypsin, b) elafin, and c) serpin;
• administering an effective amount of said glue composition to a localized region of damaged lung tissue of said subject;
• adhering said first adhering moiety to a first site bearing elastase in said localized region of damaged lung tissue of said subject;
• collapsing a first portion or all of said lung of said subject wherein said first portion comprises said localized region of damaged lung tissue;
• adhering said second adhering moiety to a second site bearing elastase in said damaged lung tissue;
• and
• re-inflating a second portion of the lung of said subject wherein said second portion does not comprise said damaged lung tissue, thereby reducing said lung volume.