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US 7,608,430 B2Granted
Interferon-γ antagonists and therapeutic uses thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsMargaret Karow, Prerna Sharma
Life of this patent
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Abstract
Polypeptides and multimeric polypeptides capable of binding interferon γ which are useful therapeutically in methods of treating interferon γ-related conditions or diseases.
Claims10
A fusion protein comprising the amino acid sequence of SEQ ID NO:7 or 9.
A fusion protein comprising the amino acid sequence of SEQ ID NO:13 or 15.
A fusion protein comprising R1,R2 and F in the N-terminus direction, and optionally a spacer sequence between R1 and R2, or R2 and F, or both,
- wherein
- R1 comprising amino acids 1-239 of SEQ ID NO:2;
- R2 comprising amino acids 28-246 of SEQ ID NO:4, wherein cysteine 174 of SEQ ID NO:4 is optionally changed to a different amino acid;
- and
- F is a multimerizing component selected from the group consisting of the Fc domain if IgG and a heavy chain of IgG;
- and
- wherein said fusion protein has an IC50 of 1-5×10−10 M in inhibiting the activity of human IFNγ as measured by a luciferase assay, or a Kd of about 1×10−11 M for human IFNγ as measured by surface plasmon resonance, or both.
4 more elements
Dependencies are inferred from the claim text.