Simian immunodeficiency virus (SIV) molecular clone encoding mutant gag gene lacking inhibitory/instability regions
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorGeorge N. Pavlakis
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Abstract
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.
Claims8
A nucleic acid construct comprising a simian immunodeficiency virus (SIV) gene having the coding sequence of the gag gene set forth in SEQ ID NO:
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Dependencies are inferred from the claim text.