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US 7,608,418 B2Granted
NT-proANP and NT-proBNP for diagnosing cardiac diseases
AssigneeRoche Diagnostics Operations, Inc.
InventorsGeorg Hess, Andrea Horsch
Life of this patent
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AssigneeRoche Diagnostics Operations, Inc.
InventorsGeorg Hess, Andrea Horsch
Estimating the term…
Described are methods for diagnosing a cardiac disease, particularly an acute cardiac event, in a patient presenting with symptoms of acute cardiac decompensation, comprising the steps of (a) measuring, typically in vitro, the level of NT-proBNP (N-terminal brain natriuretic peptide) or a variant thereof in a sample from the patient, (b) measuring, typically in vitro, the level of NIT-proANP (N-terminal atrial natriuretic peptide) or a variant thereof in a sample from the patient, (c) combining the information of the measured levels of NT-proANP and NT-proBNP, wherein an increased level of NT-proANP in presence of a non-increased or weakly increased level of NT-proBNP indicates the presence of an acute cardiac event, or wherein an increased level of NT-proANP in presence of a highly increased level of NT-proBNP indicates the presence of a chronic cardiac disease. The methods also allow distinguishing an acute cardiac event from decompensation of a chronic cardiac disease. Described also are corresponding kits and to methods of treatment of cardiac diseases.
A method for distinguishing an acute cardiac event from a chronic cardiac disease in a patient presenting with symptoms of acute cardiac decompensation, the method comprising the steps of
A method for recommending initiation of treatment of a patient for a cardiac disease, wherein the patient presents with symptoms of acute cardiac decompensation, the method comprising the steps of
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