Back to results
US 7,608,400 B2Granted
Methods for detecting a cyclophilin B SNP associated with HERDA
AssigneeThe Regents of the University of California
InventorsDanika Bannasch, Robert Tryon, Stephen White
Life of this patent
Estimating the term…
Abstract
This invention provides compositions and methods for identification of carriers of Hereditary Equine Regional Dermal Asthenia (HERDA) in equine species. In particular, this invention identifies a single nucleotide polymorphorism (SNP) in cyclophlin B that can be used to identify carriers of HERDA and individuals affected by HERDA.
Claims7
A method for detecting a single nucleotide polymorphism (SNP) associated with hereditary equine regional dermal asthenia (HERDA) phenotype in an equine, the method comprising:
- isolating from the equine a DNA molecule comprising a cyclophilin B (PPIB) sequence at least 95% identical to SEQ ID NO:
- 1 or an mRNA molecule transcribed from the PPIB sequence;
- and
- detecting a G to A substitution at position 115 counted from the start codon of the PPIB sequence;
- wherein the presence of a single copy of G to A substitution at position 115 of the PPIB sequence indicates that the equine is carrier for the SNP associated with HERDA and the presence of two copies of a G to A substitution at position 115 indicates that the animal is affected with HERDA.
2 more elements
Dependencies are inferred from the claim text.