Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
AssigneeRappaport Family Institute for Research in the Medical Sciences
InventorAndrew P. Levy
Life of this patent
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Abstract
A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said anti oxidant therapy, whereby a patient having a haptoglobin 2-2 phenotype benefits from anti oxidant therapy more than a patient having a haptoglobin 1-2 phenotype or a patient having a haptoglobin 1-1 phenotype.
Claims20
A method of determining a potential of a diabetic patient over 55 years of age to benefit from vitamin E therapy for prevention of myocardial infarction, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said vitamin E therapy, wherein said benefit from said vitamin E therapy to a patient having a haptoglobin 2-2 phenotype is greater compared to patients having haptoglobin 1-2 phenotype or haptoglobin 1-1 phenotypes.
A method of determining the importance of reducing oxidative stress by administering vitamin E in a diabetic patient over 55 years of age so as to prevent myocardial infarction, the method comprising the step of determining a haptoglobin phenotype of the diabetic patient thereby determining the importance of reducing the oxidative stress by administering vitamin E in the specific diabetic patient, wherein said importance of reducing oxidative stress by administering vitamin E is greater in a patient having a haptoglobin 2-2 phenotype compared to patients having haptoglobin 1-2 phenotype or haptoglobin 1-1 phenotypes.
Dependencies are inferred from the claim text.