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US 7,608,281 B2Granted
Composition and use of RAR antagonists for promoting chondrogenesis
AssigneeT. Michael Underhill
InventorsTully Michael Underhill, Andrea Dawn Weston
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Abstract
The invention provides compositions comprising a RAR antagonist for promoting chondrogenesis and to methods employing such compositions for treating cartilage and associated bone abnormalities resulting from injury or disease and for ex vivo tissue engineering.
Claims15
A method for treating degenerative joint disease characterized by cartilage degeneration comprising:
- delivering a therapeutically effective amount of an RAR antagonist to the site of disease to stimulate chondrogenesis at said site of disease, wherein said RAR antagonist is provided within a composition comprising a pharmaceutically acceptable carrier and a chondrogenic stimulator.
A method for treating degenerative joint disease characterized by cartilage degeneration comprising:
- delivering a therapeutically effective amount of an RAR antagonist to the site of disease to stimulate chondrogenesis at said site of disease, wherein said method comprises implanting a device comprising:
- (a) an implantable biocompatible carrier;
- and
- (b) the RAR antagonist dispersed within or on said carrier,
- wherein said carrier comprises demineralized bone, protein-extracted bone, particulate bone, allogenic bone, xenogenic bone or combinations thereof.
2 more elements
Dependencies are inferred from the claim text.